The initiation of these studies follows the successful completion of a
phase 1 dose escalation study of ALKS 33 in healthy volunteers.
“ALKS 33 is an excellent example of how
ALKS 33 Study Designs
ALK33-004 is a phase 1, randomized, single-blind, placebo-controlled, single-dose study designed to test the ability of ALKS 33 to block the effects of an opioid agonist, remifentanil, a commercially available analgesic. Approximately 24 healthy, non-dependent, opioid-experienced subjects will be randomized to receive a placebo dose as well as one of two dose levels of ALKS 33. The ability of ALKS 33 to block the effects of remifentanil will be measured by pupillometry assessments and subjective measures of opioid effects. The pharmacokinetics and safety of ALKS 33 will also be evaluated.
ALK33-003 is a phase 1 randomized, double-blind, placebo-controlled, multi-dose study designed to assess the steady-state pharmacokinetics, safety and tolerability of ALKS 33. Approximately 30 healthy subjects will be randomized to receive seven consecutive, daily oral doses of one of two dose levels of ALKS 33 or placebo.
About ALKS 33
ALKS 33 is an oral opioid modulator that builds on Alkermes’ scientific
expertise in brain reward pathways as well as the company’s clinical and
commercial knowledge in the field of addiction. In
About Opioid Receptor Pathways
Opioid receptor pathways have biological activity throughout the body including the brain, gastrointestinal system, immune system and cardiovascular system. Consequently, opioid receptor pathways play a key role in a broad range of nervous system disorders such as pain, addiction, psychiatric disorders, gastrointestinal disorders and immune disorders. Opioid modulators can act as agonists, antagonists or partial agonists at opioid receptors throughout the body. Emerging biological research and new medicinal chemistry insights now allow for the development of novel opioid modulators with the potential to show enhanced activity at opioid receptor sites and could ultimately lead to improved therapeutic options.
About
Certain statements set forth above may constitute forward-looking
statements within the meaning of the Private Securities Litigation
Reform Act of 1995, including, but not limited to the potential
therapeutic value of Alkermes’ proprietary molecules targeting opioid
receptors, including ALKS 33, and Alkermes’ plans to continue
development of such proprietary molecules. Although the company believes
that such statements are based on reasonable assumptions within the
bounds of its knowledge of its business and operations, the
forward-looking statements are neither promises nor guarantees and the
company’s business is subject to significant risk and uncertainties and
there can be no assurance that its actual results will not differ
materially from its expectations. These risks and uncertainties include,
among others: whether the phase 1 clinical trials discussed in this
release will be completed on time or at all; potential changes in cost,
scope and duration of the clinical trials; whether the company’s product
candidates will demonstrate sufficient efficacy and safety; and
decisions by the
VIVITROL® is a registered trademark of
Source:
Alkermes Contacts:
For
Investors:
Rebecca Peterson, 617-583-6378
or
For Media:
Jennifer
Snyder, 617-583-6166