Ownership

Shareholders   Holders Value ($MM) % O/S Shares Institution 110 219.39 77.0 42,227,932 Mutual Fund 163 64.97 26.9 14,744,182 Insider * 22 85.12 27.0 14,828,432

*Insider values reflect direct beneficial ownership.

Rotation   Holders Value Chg ($MM) % O/S Share Change Buyers 66 75.50 29.1 15,977,337 Sellers 28 -53.63 17.5 -9,594,292 Net -- 21.86 11.6 6,383,045

Concentration   Value ($MM) % O/S Shares Top 10 Inst. 167.04 58.9 32,290,119 Top 20 Inst. 193.61 67.8 37,181,829 Top 50 Inst. 213.27 74.8 41,031,142 Total Inst. 219.39 77.0 42,227,932

Style   Holders Value ($MM) % Inst Shares Shares Index 16 33.12 14.4 5,915,163 Growth 18 10.34 4.5 1,846,589     Core Growth 12 5.07 2.2 904,490     Aggressive Growth 3 3.80 1.7 679,195     Growth 3 1.47 0.6 262,904 Income 2 .98 0.4 174,635     Income Value 2 .98 0.4 174,635 Other 44 134.28 64.2 26,445,171     GARP 18 65.72 28.5 11,741,163     Hedge Fund 14 34.75 15.1 6,205,220     VC Private Equity 1 13.01 11.6 4,784,689     Sector Specific 1 19.29 8.4 3,444,647     Broker Dealer 10 1.51 0.7 269,452 Value 19 37.86 16.5 6,797,334     Core Value 15 28.02 12.2 5,036,758     Deep Value 4 9.84 4.3 1,760,576

Top Holders   Shares Held % O/S Share Change Filing Date Fidelity Management & Research 6,760,769 12.3 2,296,714 06/30/10 Venrock 4,784,689 8.7 4,784,689 12/22/09 Wellington Management Company, LLP 4,316,763 7.9 -184,500 06/30/10 FrontPoint Partners LLC 3,856,455 7.0 2,956,455 06/30/10 Biotechnology Value Fund, Inc. 3,444,647 6.3 -2,170,300 06/30/10 BlackRock Institutional Trust Company, N.A. 2,955,047 5.4 54,437 06/30/10 T. Rowe Price Associates, Inc. 2,138,239 3.9 327,410 06/30/10 Dimensional Fund Advisors, LP 1,548,847 2.8 -167,047 06/30/10 Pyramis Global Advisors, LLC 1,460,044 2.7 1,460,044 06/30/10 Vanguard Group, Inc. 1,024,619 1.9 28,316 06/30/10

Ownership data based on most recent publicly available data according to Thomson Financial.