The posters (abstracts #826 and #829) titled "Kinect 1 Extension: 12-week treatment of Tardive Dyskinesia with NBI-98854" and "Kinect 2: NBI-98854 Treatment of Moderate to Severe Tardive Dyskinesia" are available throughout the day, with the guided poster session occurring from
"Having both of these posters accepted for presentation at this important meeting allows us to share the breadth and depth of our tardive dyskinesia clinical efforts with the worldwide experts in movement disorders," said
About NBI-98854
VMAT2 is a protein concentrated in the human brain that is primarily responsible for re-packaging and transporting monoamines (dopamine, norepinephrine, serotonin, and histamine) in pre-synaptic neurons. NBI-98854, developed in the Neurocrine laboratories, is a novel, highly-selective VMAT2 inhibitor that modulates dopamine release during nerve communication, while at the same time having minimal impact on the other monoamines, thereby reducing the likelihood of "off target" side effects. NBI-98854 is designed to provide low, sustained, plasma and brain concentrations of active drug to minimize side effects associated with excessive monoamine depletion. The Company is currently preparing for an end of phase II meeting with the
NBI-98854 may also be useful in other disorders such as Huntington's chorea, schizophrenia, Tourette's syndrome, and tardive dystonia.
About
In addition to historical facts, this press release may contain forward-looking statements that involve a number of risks and uncertainties. Among the factors that could cause actual results to differ materially from those indicated in the forward-looking statements are risks and uncertainties associated with Neurocrine's business and finances in general, as well as risks and uncertainties associated with the Company's VMAT2 program and Company overall. Specifically, the risks and uncertainties the Company faces with respect to the Company's VMAT2 program include, but are not limited to; risk that NBI-98854 will not proceed to later stage clinical trials and risk that the Company's clinical trials will fail to demonstrate that NBI-98854 is safe and effective as well as the other risks described in the Company's report on Form 10-K for the year ended
SOURCE
Neurocrine Biosciences, Investor Relations, (858) 617-7600