Press Release Details

Study Represents Largest  DNA Mapping Effort Undertaken in U.S. from a Single Population

REYKJAVIK, ICELAND, and SALT LAKE  CITY – Intermountain Healthcare and  deCODE genetics have announced a major global collaboration and study focused  on discovering new connections between genetics and human disease that will  involve the collection of half a million DNA samples.

The initiative, called the  HerediGene: Population Study, represents the largest and most comprehensive DNA  mapping effort to date in the United States from a single population. For the  study, which is voluntary and free to participants, Intermountain teams will  work with deCODE to analyze the genomes of 500,000 people from Intermountain’s  patient population, primarily in Utah and Idaho.

Intermountain Healthcare is a  Utah-based not-for-profit integrated healthcare delivery network, and deCODE  Genetics is a wholly owned subsidiary of Amgen based in Reykjavik, Iceland. The  collaborative effort combines Intermountain’s internationally-recognized  expertise in precision medicine and clinical care with deCODE’s world-class  expertise in human population genetics.

“While the 500,000 samples will  be collected primarily from patients in Utah, the research is expected to have  a global impact as medications, treatments, and healthcare innovations that can  benefit patients universally are developed from the findings,” said Lincoln  Nadauld, MD, PhD, Intermountain’s chief of precision health. “The collaboration  is noteworthy and unique in its size, scope, and immediate application to  patient care.”

Participants in the study will  consent to the testing and have the option to receive their genetic results  report, if a clinically significant gene mutation is identified. The data will  be de-identified to ensure anonymity before it is utilized in research to help  medical professionals better understand the human genome, which will enhance  their ability to predict and prevent diseases such as breast cancer, colon  cancer, and heart disease.

“This  unique collaboration is expected to uncover new insights into some of society’s  most debilitating diseases,” noted Kári Stefánsson, MD, Dr. Med., founder and  chief executive officer of deCODE genetics. “Our partnership with Intermountain  Healthcare is important as we continue to identify and validate human disease  targets. These potential discoveries will allow deCODE and Amgen to rapidly  develop new medicines that reach the right disease targets.”

Intermountain will leverage its renowned  precision genomics efforts to improve patient outcomes and transform medicine. Intermountain’s  precision medicine team analyzes individual differences in genetics,  environments, and lifestyles and helps medical professionals specifically target  the illnesses of each patient and identify the treatments that will best help  them.

“Better health and being able to  cure common diseases is the promise of precision medicine, but it’s not  happening fast enough,” said Marc Harrison, MD, president and chief executive  officer at Intermountain Healthcare. “For too long, the genetic code to better  health has been locked. This collaboration with deCODE unlocks that insight so  we can rapidly advance well-being – not only for ourselves and our families,  but for generations to come.”

Insights from the collaboration may power  fundamental changes to better understand the human genome, improve health, and  prevent common diseases.

For more information on the study, please go to  Intermountainhealthcare.org/heredigene.

About deCODE genetics
Based in Reykjavik, Iceland,  deCODE is a global leader in analyzing and understanding the human genome.  Using its unique expertise and population resources, deCODE has discovered  genetic risk factors for dozens of common diseases. Understanding the genetics  of disease can create new means of diagnosing, treating and preventing disease.  deCODE is a wholly-owned subsidiary of Amgen.

About Intermountain
  Intermountain Healthcare is a  Utah-based not-for-profit system of 24 hospitals, 160 clinics, a Medical Group  with some 2,300 employed physicians and advanced care practitioners, a health  insurance company called SelectHealth, and other health services. Intermountain  is widely recognized as a leader in transforming healthcare through  evidence-based best practices, high quality, and sustainable costs. For more  information about Intermountain, visit intermountainhealthcare.org.

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Media Contacts:
Intermountain Healthcare:                                                       deCODE  genetics:
Brad Gillman:  brad.gillman@imail.org/385-315-8949          Jon Gustafsson: jon@decode.is/+354 664 1905