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October 24, 2013 at 7:00 AM EDT

Verastem Announces Presentations at the 2013 World Conference on Lung Cancer

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Oct. 24, 2013-- Verastem, Inc. (NASDAQ:VSTM), focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, today announced scheduled poster presentations at the 2013 International Association for the Study of Lung Cancer (IASLC) World Conference on Lung Cancer which is taking place October 27-30, 2013 in Sydney, Australia.

 

Title:

A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of VS-6063 as Maintenance Therapy in Subjects with Malignant Pleural Mesothelioma which has Not Progressed on at least 4 Cycles of Pemetrexed/Platinum Therapy (COMMAND)

Abstract #:

P2.14-014

Date and Time:

Tuesday, October 29, 2013 9:30 – 4:30 PM

Session:

Poster Session 2; Mesothelioma

Location:

Exhibit Hall, Ground Level
 

Title:

  Malignant Mesothelioma Lacking Merlin Shows Enhanced Sensitivity to the FAK Inhibitor VS-6063: Evaluation of Merlin/NF2 Status in Clinical Samples

Abstract #:

P2.06-048

Date and Time:

Tuesday, October 29, 2013 9:30 – 4:30 PM

Session:

Poster Session 2; Prognostic and Predictive Biomarkers

Location:

Exhibit Hall, Ground Level
 

About VS-6063

VS-6063 (defactinib) is an oral compound designed to target cancer stem cells through the potent inhibition of focal adhesion kinase (FAK). Cancer stem cells are an underlying cause of tumor resistance to chemotherapy, recurrence and ultimate disease progression. Research by Robert Weinberg, Ph.D., scientific cofounder and chair of Verastem’s Scientific Advisory Board, and Verastem has demonstrated that the FAK pathway is critical for the growth and survival of cancer stem cells. VS-6063 is currently being studied in the registration-directed COMMAND trial in mesothelioma, a Phase 1/1b study in combination with weekly paclitaxel in ovarian cancer, a Phase 1 study in Japan and a Phase 2 trial in KRAS-mutated Non-Small Cell Lung Cancer. VS-6063 has been granted orphan drug designation in the U.S. and E.U. for use in mesothelioma.

About Verastem, Inc.

Verastem, Inc. (NASDAQ: VSTM) is discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells. Cancer stem cells are an underlying cause of tumor recurrence and metastasis. Verastem is developing small molecule inhibitors of signaling pathways that are critical to cancer stem cell survival and proliferation: FAK, PI3K/mTOR and Wnt. For more information, please visit www.verastem.com.

Forward-looking statements:

This press release includes forward-looking statements about the Company’s strategy, future plans and prospects, including statements regarding the development of the Company’s compounds, including VS-6063, or defactinib, and the Company’s FAK and diagnostic programs generally, the timeline for clinical development and regulatory approval of the Company’s compounds, the expected timing for the reporting of data from ongoing studies, the structure of the Company’s planned clinical trials and the Company’s ability to fund operations. The words “anticipate,” “appear,” “believe,” “estimate,” “expect,” “intend,” “may,” “plan,” “predict,” “project,” “target,” “potential,” “will,” “would,” “could,” “should,” “continue,” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Each forward-looking statement is subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statement. Applicable risks and uncertainties include the risks that the preclinical testing of the Company’s compounds and preliminary data from clinical trials may not be predictive of the results or success of later clinical trials, that data may not be available when we expect it to be, that the Company will be unable to successfully complete the clinical development of its compounds, including VS-6063, that the development of the Company’s compounds will take longer or cost more than planned, and that the Company’s compounds will not receive regulatory approval or become commercially successful products. Other risks and uncertainties include those identified under the heading “Risk Factors” in the Company’s Annual Report on Form 10-K for the year ended December 31, 2012 and in any subsequent SEC filings. The forward-looking statements contained in this presentation reflect the Company’s current views with respect to future events, and the Company does not undertake and specifically disclaims any obligation to update any forward-looking statements.

Source: Verastem, Inc.

Verastem, Inc.
Brian Sullivan, 617-252-9314
bsullivan@verastem.com

Investor Contact

getty
Julissa Viana

Investor Relations
investors@verastem.com

Ryan Porter

Argot Partners
+1 212-600-1902
ryan.porter@argotpartners.com