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Scientific Publications
Z944 and T-type calcium channel modulators Format
1. Z944: A first in-class T-type calcium channel blocker effective in nonclinical models of acute and inflammatory pain,” Glenn F. Short III, PhD, APS 2013
2. Tringham E et al. T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures. Science and Translational Medicine, 15 February 2012, Vol 4 Issue 121.
Nav 1.7 channel modulators Format
1. Hildebrand ME et al. A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain. PAIN® (2011), doi:10.1016/j.pain.2010.12.035
2. A Novel Small Organic Compound Attenuates Neuropathic Pain by Stabilizing the Slow Inactivated State of Sodium and Calcium Channels, Spring Pain Conference 2010
Combination High Throughput Screening (cHTS™) Services Format

1. Synergistic drug combinations tend to improve therapeutically relevant selectivity: Nature Biotechnology, Vol 27, No 7, July 2009

2. Rickles, RJ et al. “Adenosine A2A and beta-2 adrenergic receptor agonists: novel selective and synergistic multiple myeloma targets discovered through systematic combination screening.” Mol Cancer Ther. 2012 Jul;11(7):1432-42.
3. Rickles, RJ et al. “Adenosine A2A receptor agonists and PDE inhibitors: a synergistic multitarget mechanism discovered through systematic combination screening in B-cell malignancies.” Blood. 2010 Jul 29;116(4):593-602.
4. FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection, Johansen, et al, Science Translational Medicine, 19 June 2013 Vol 5 Issue 190 190ra79.
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