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SENOMYX, INC. ANNOUNCES THE APPOINTMENT OF JOHN POYHONEN TO THE POSITION OF CHIEF FINANCIAL OFFICERLA JOLLA, CA (May 24, 2004) - Senomyx, Inc. (www.senomyx.com) announced today that John W. Poyhonen has been appointed to the position of Chief Financial and Business Officer. Mr. Poyhonen has served as Senomyx's Vice President and Chief Business Officer since joining the Company in October, 2003 and will retain his current responsibilities in addition to his new role as Chief Financial Officer.

“Since joining Senomyx, John has made a significant impact on the progress of our company,” said Kent Snyder, President and CEO of Senomyx. “John is a highly capable individual and we look forward to his continued contributions as we move forward.”

Prior to joining Senomyx, Mr. Poyhonen served in various commercial leadership positions at Agouron Pharmaceuticals, a Pfizer company, most recently as Vice President of National Sales. Prior to holding this position, Mr. Poyhonen served as Vice President of Marketing and Vice President of National Accounts. Mr. Poyhonen received his B.A. in Marketing from Michigan State University and his M.B.A. from the University of Kansas.

About Senomyx, Inc.

Senomyx is the leading biotechnology company using proprietary taste receptor-based assays and screening technologies to discover and develop novel flavors and flavor enhancers for the packaged food and beverage industry. Senomyx has entered into product discovery and development collaborations with four of the world's leading packaged food and beverage companies: Campbell Soup Company, The Coca-Cola Company, Kraft Foods Global, Inc. and Nestlé SA. Senomyx's current programs focus on the development of flavors or flavor enhancers in three taste areas, including savory, sweet and salt.