ST. LOUIS, March 3 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL)
today announced the global release of the MISSION(R) LentiPlex(TM) Pooled
Human and Murine shRNA Libraries (http://www.sigma-aldrich.com/lentiplex).
Using the shRNA collections of The RNAi Consortium (TRC), the MISSION
LentiPlex Pooled shRNA Libraries enable rapid, genome-wide RNAi screening at
the bench-top level in a convenient and powerful, pooled lentiviral format.
As a member of both TRC-1 and TRC-2 collaborations, Sigma-Aldrich is the
exclusive commercial source for access to TRC shRNA libraries in lentiviral
format.
The MISSION LentiPlex Pooled shRNA Libraries were developed from the
entire TRC-1 human and mouse collections of more than 158,000 shRNA constructs
targeting approximately 16,000 human genes and approximately 16,000 mouse
genes. Combining Sigma-Aldrich's high-throughput lentiviral production
methodologies with the pooled library format enables researchers to perform
genome-wide RNAi screens on various cell types, rapidly and efficiently
discovering new targets without a large investment in infrastructure.
"Sigma-Aldrich is committed to providing customers powerful and unique
screening formats that fully leverage the content of TRC," said Tim Fleming,
Director of Global Commercial Marketing at Sigma-Aldrich. "The pooled
lentiviral format of this product is expected to make the discovery potential
of the TRC collection accessible to any researcher with minimal reagent, time
or capital equipment investment."
LentiPlex enables researchers to screen for novel phenotypes in relevant
cell lines and study gene function and disease, both in standard cell lines
and difficult cell types such as primary, non-dividing, growth-arrested or
terminally differentiated cells that are typically resistant to standard siRNA
transfection or other viral delivery systems. In addition, Sigma-Aldrich's
shRNA libraries include a U6 promoter for shRNA expression in a wide variety
of cell lines including embryonic stem cells. These characteristics mean
researchers can now conduct high quality pooled shRNA screens in the cell
lines of their choice.
The MISSION LentiPlex Pooled shRNA Libraries add to Sigma-Aldrich's suite
of MISSION shRNA products, which include the MISSION TRC-1 shRNA human
(MISSION TRC-Hs1.0) and murine (MISSION TRC-Mm1.0) collections of whole genome
arrayed libraries, gene family sets or individually prepared clones in
glycerol, purified DNA or lentiviral formats. For more information on the
MISSION LentiPlex Pooled shRNA Library, please visit
http://www.sigma-aldrich.com/lentiplex.
About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High
Technology company. Its biochemical and organic chemical products and kits are
used in scientific research, including genomic and proteomic research,
biotechnology, pharmaceutical development and as key components in
pharmaceutical, diagnostic and other high technology manufacturing. The
Company has customers in life science companies, university and government
institutions, hospitals, and in industry. Over one million scientists and
technologists use its products. Sigma-Aldrich operates in 37 countries and has
7,900 employees providing excellent service worldwide. Sigma-Aldrich is
committed to Accelerating Customer Success through Innovation and Leadership
in Life Science, High Technology and Service. For more information about
Sigma-Aldrich, please visit its award-winning Web site at
http://www.sigma-aldrich.com.
Sigma-Aldrich, MISSION and LentiPlex are registered trademarks of
Sigma-Aldrich Biotechnology LP and Sigma-Aldrich Co.
SOURCE: Sigma-Aldrich
CONTACT: Sean Battles of Sigma-Aldrich, +1-314-286-7616,
sean.battles@sial.com
/Photo: http://www.newscom.com/cgi-bin/prnh/20050215/CGSIGMAALLOGO
http://photoarchive.ap.org
photodesk@prnewswire.com
Web Site: http://www.sigma-aldrich.com
